EASE-CF: dietitian-led weight-loss intervention for adults with cystic fibrosis and excess weight: protocol for a feasibility randomised controlled trial

Advances in cystic fibrosis (CF) care have coincided with an increasing prevalence of excess body weight in this population, which may contribute to cardiometabolic and respiratory morbidity. However, evidence to guide intentional weight loss in this population is limited and safety concerns remain due to the established positive association between body weight and lung function. Delivering weight-loss interventions in CF is likely to be complex because of CF-specific factors, high treatment burden and embedded dietary advice focused on high-energy, high-fat diets for weight gain. To inform the design of a future definitive randomised controlled trial (RCT), we plan to test the feasibility, acceptability and safety of a dietitian supported weight-loss intervention compared with routine care.