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Effects of a remotely supervised resistance training program on muscle strength and body composition in adults with cystic fibrosis: Randomized controlled tria

Alicia Sosa-Pedreschi, Márcio Vinícius Fagundes Donadio, Tamara Iturriaga-Ramírez, Thomas Yvert, Fernanda Pérez-Salazar, Catalina Santiago-Dorrego, Olga Barceló-Guido, Verónica Sanz-Santiago, Rosa Girón, Rosa Mar Gómez Punter, Margarita Rubio-Alonso, Margarita Pérez-Ruiz

Jan 18, 2024


Introduction: Among the limited studies on physical exercise interventions in adults with cystic fibrosis (CF), few have specifically addressed the improvement of peripheral muscle strength and body fat-free mass. The aim of this study was to examine the impacts of a remotely supervised, individualized 8-week resistance training program of moderate to high intensity on strength and body composition in these subjects.

Methods: This was a randomized controlled trial performed in adults with CF. The exercise group (EX) performed three 1-h resistance training sessions per week over 8 weeks. The control group (CON) followed the physical activity recommendations of their physician. The main outcomes were muscle strength and body composition, with secondary measures including pulmonary function and quality of life. Two-way repeated measures analysis was used.

Results: In 23 participants (age 32.13 ± 7.72 years), the intervention showed a significant beneficial effect on leg press strength, with a large effect size, both in absolute (p = 0.011; η2p2 = 0.281) and relative (p = 0.007; η2p2 = 0.310) terms. Large intervention effects were observed on total fat mass (p < 0.001; η2p2 = 0.415), body adiposity index (p < 0.001; η2p2 = 0.436), and fat mass index (p < 0.001; η2p2 = 0.445), all showing reduction in the EX group. In addition, significant large size effects were detected on total fat-free mass (p = 0.046; η2p2 = 0.177), trunk fat-free mass (p = 0.039; η2p2 = 0.188), and fat-free mass index (p = 0.048; η2p2 = 0.174), all favoring exercise. No significant effects were observed on pulmonary function and quality of life.

Conclusions: An 8-week remotely supervised resistance training program, with moderate to high intensity, effectively improved lower limb muscle strength and body composition.

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