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Impact of Elexacaftor/Tezacaftor/Ivacaftor on Fecal Elastase-1 in Children With Cystic Fibrosis

Senthilkumar Sankararaman, Leesa Prunty, Catherine Pamer, Aravind Thavamani, Erica Roesch, Teresa Schindler

Jun 17, 2025

In our cohort of 35 children, 7 (20%) were noted to have a positive change in FE-1 from the baseline value of ≥ 100 µg/g post-ETI. Further prospective multicenter studies will help identify predictive factors associated with improvement in FE-1 after initiation of CFTR-directed modulator therapies. is.

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