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Relationship between skeletal muscle indicators and clinical outcomes in cystic fibrosis is modified by adiposity and CFTR modulator use: A cross-sectional analysis

Lucia A Gonzalez Ramirez, Pichatorn Suppakitjanusant, Tasha M Burley, Swati Zaveri, Arlene A Stecenko, William R Hunt, Ryan A Harris, Virginia A Stallings, Elizabeth A Ivie, Chris Driggers, Jose N Binongo, Thomas R Ziegler, Jessica A Alvarez

Jun 6, 2025

https://doi.org/10.1016/j.ajcnut.2025.09.019

PwCF exhibited lower muscle mass, strength, and quality than controls, with muscle function linked to glucose tolerance. Lung function relationships with muscle mass differed by CFTR modulator use, while excess adiposity attenuated strength-related functional benefits. This study highlights the need for personalized approaches to CF management.

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